15 Mar EduWorkShop at EuroMedLab 2019
Plasma Calprotectin: A promising early biomarker for the diagnosis of bacterial infections and sepsis.
This educational workshop focuses on the role of calprotectin in early diagnosis of bacterial infections and its performance in differentiation between sepsis and non-infectious causes of systemic inflammation.
Diagnosis of severe infections and sepsis: Challenges with current biomarkers
By Jordi Rello, MD, PhD (Spain)
Calprotectin as a risk marker in emergency department patients with acute dyspnea
By Toralph Ruge, MD, PhD (Sweden)
A promising early biomarker for the diagnosis of bacterial infections and sepsis
Educational WS @ EuroMedlab 21st May 2019 16:00-17:00.
Early diagnosis: bacterial or viral infection?
The rapidly growing problem with antibiotic resistance has resulted in demands for more specific and restrictive use of antibiotics. Biomarkers with ability to diagnose an infection in early stage and distinguish between bacterial and viral infection can possibly reduce overuse of antibiotics.
Importance of early response to bacterial infections
Calprotectin is released upon activation of neutrophils  as a part of the early response to bacterial infection. The ability to predict and detect an infection as early as possible, can:
- aid in a therapeutic decision making
- add information about diagnosis and risk stratification, which again can
- reduce the morbidity and mortality
- improve patient outcome.
Differentiate between SIRS and sepsis
This is especially important in the differentiation between systemic inflammatory response syndrome (SIRS) and sepsis. An early diagnosis of sepsis, and hence an early onset of the appropriate therapy is crucial for the patient outcome [2, 3].
Rapid turn around time
The rapid turn-around-time of a plasma/serum calprotectin test based on the Particle-Enhanced Turbidimetric method combined with the early release of calprotectin upon inflammation and/or infection suggest that calprotectin is a promising biomarker with widespread clinical use.
Interested to participate in our workshop about Plasma Calprotectin at EuroMedLab? Contact us through the form below and one of our Product Managers will contact you shortly.
- Voganatsi A, Panyutich A, Miyasaki KT, Murthy RK. Mechanism of extracellular release of human neutrophil calprotectin complex. J. Leukoc. Biol. 70 (1), 130 –134 (2001).
- Kumar A, Roberts D, Wood KE et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 34(6), 1589 –1596 (2006).
- Dellinger RP, Levy MM, Rhodes A et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med.39(2), 165–228 (2013).